孔祥银

孔祥银，男，1988年毕业于山东医科大学医学系，获学士。中国科学院上海生命科学研究院研究员、博导。2002年至今任中国科学院上海生命科学研究院/上海交通大学医学院健康科学研究所研究员，博士生导师，课题组长。孔祥银研究员主要研究方向为分子遗传学·

人物经历

1983年9月-1988年7月，孔祥银就读于山东医科大学医学系，毕业获得医学学士学位。

1988-1995年中国医学科学院血液学研究所先后任研究实习员，助理研究员，期间1992-1993年于协和医科大学研究生院在职研究生学习；

1995-1997年马克斯·普朗克分子遗传学研究所访问学者；

1997—2002年中科院上海生物工程研究中心工作，先后任助理研究员，副研究员，研究员

主要成果

成功克隆了遗传性牙本质发育不全Ⅰ型基因(DSPP)，并发现该基因的部分突变还引起进行性高频耳聋，证实了DSPP不仅参与牙本质的发育，特别是牙本质的矿化过程，还参与了听觉系统的发育，建立了牙齿发育和内耳发育之间的联系。从而为阐明相关疾病的发生机制奠定了基础，开辟了新的思路。研究论文发表在2001《Nature Genetics》；成功克隆了遗传性儿童性白内障的致病基因热休克蛋白转录因子4(HSF4)；在国际上首次发现热休克蛋白转录因子是导致遗传性儿童性白内障的致病基因，发现HSF4蛋白脱氧核糖核酸结合区在白内障发生中具有重要作用，首次将热休克蛋白的合成与白内障的发生联系起来为该病的诊断和治疗提供了新的理论依据，加深了对白内障发生的分子机理认识。

研究论文发表在2002《Nature Genetics》；在国际上首次发现CYLD突变引起遗传性毛发上皮瘤；首次发现CYLD基因的不同突变突变引起遗传性毛发上皮瘤，研究结果于2002年上海市HGM2002会议公布，论文发表于2004年《Human Mutation》。

主要论文

（1）Global analysis of T-cell groups reveals immunological features and common 抗原 targets of digestive tract tumors, Global analysis of T-cell groups reveals immunological features and common antigen targets of digestive tract tumors, J Cancer Res Clin Oncol, 2024.

（2）Targeting Tumor Heterogeneity by Breaking a Stem Cell and Epithelial Niche Interaction Loop, Targeting Tumor Heterogeneity by Breaking a Stem Cell and Epithelial Niche Interaction Loop, Adv Sci (Weinh), 2024, 第6作者.

（3）Oleic acid availability impacts thymocyte preprogramming and subsequent peripheral Treg cell differentiation, Oleic acid availability impacts thymocyte preprogramming and subsequent peripheral Treg cell differentiation, Nat Immunol, 2024, 第12作者.

（4）Protocol for PPP1R15A-inhibited mouse model establishment with subcutaneous B16F1 tumor and single-cell analysis, Protocol for PPP1R15A-inhibited mouse model establishment with subcutaneous B16一级方程式锦标赛 tumor and single-细胞 analysis, STAR Protoc, 2023.

（5）A novel long noncoding 核糖核酸 SP100-AS1 induces radioresistance of colorectal cancer via sponging miR-622 and stabilizing ATG3, A novel long noncoding RNA SP100-AS1 induces radioresistance of colorectal cancer via sponging miR-622 and stabilizing ATG3, Cell Death Differ, 2023, 第6作者.

（6）Single-细胞 核糖核酸 sequencing reveals the suppressive effect of PPP1R15A inhibitor Sephin1 in antitumor immunity, Single-cell RNA sequencing reveals the suppressive effect of PPP1R15A inhibitor Sephin1 in antitumor immunity, iScience, 2023.

（7）Escaping but not the inactive X-linked protein complex coding genes may achieve X-chromosome dosage compensation and underlie X chromosome inactivation-related diseases, Escaping but not the inactive X-linked protein complex coding genes may achieve X-chromosome dosage compensation and underlie X chromosome inactivation-related diseases, Heliyon, 2023.

（8）Remodeling of H3K9me3 during the pluripotent to totipotent-like state transition, Remodeling of H3K9me3 during the pluripotent to totipotent-like state transition, Stem Cell Reports, 2023, 第12作者.

（9）Oleic acid availability impacts thymocyte preprogramming and subsequent peripheral T reg cell differentiation, NATURE IMMUNOLOGY, 2023, 第 20 作者.

（10）Targeting KRAS-mutant stomach/colorectal tumors by disrupting the ERK2-p53 complex, Targeting KRAS-mutant stomach/colorectal tumors by disrupting the ERK2-p53 complex, Cell Rep, 2023, 第12作者.

（11）Intact regulation of G1/S transition renders esophageal squamous cell carcinoma sensitive to PI3Kα inhibitors, Intact regulation of G1/S transition renders esophageal squamous cell carcinoma sensitive to PI3K inhibitors, Signal Transduct Target Ther, 2023, 第12作者.

（12）Longitudinal immune profiling reveals dominant epitopes mediating long-term humoral immunity in COVID-19-convalescent individuals, Longitudinal immune profiling reveals dominant epitopes mediating long-term humoral immunity in COVID-19-convalescent individuals, J Allergy Clin Immunol, 2022, 第12作者.

（13）Genome-wide gain-of-function screening identifies EZH2 mediating resistance to PI3Kα inhibitors in oesophageal squamous cell carcinoma, Genome-wide gain-of-函数 screening identifies EZH2 mediating resistance to PI3K inhibitors in oesophageal squamous cell carcinoma, Clin Transl Med, 2022, 第12作者.

（14）SCD1 Sustains Homeostasis of Bulge Niche via Maintaining Hemidesmosomes in Basal Keratinocytes, SCD1 Sustains Homeostasis of Bulge Niche via Maintaining Hemidesmosomes in Basal Keratinocytes, Adv Sci (Weinh), 2022, 第12作者.

（15）Occludin is a target of Src kinase and promotes lipid secretion by binding to BTN1a1 and XOR, Occludin is a target of Src kinase and promotes lipid secretion by binding to BTN1a1 and XOR, PLoS Biol, 2022, 第12作者.

（16）Characterization of the Blood and Cerebrospinal Fluid Microbiome in Children with Bacterial Meningitis and Its Potential Correlation with Inflammation, Characterization of the Blood and Cerebrospinal Fluid Microbiome in Children with Bacterial Meningitis and Its Potential Correlation with Inflammation, mSystems, 2021.

（17）PI3Kα inhibitor CYH33 triggers antitumor immunity in murine breast cancer by activating CD8+T cells and promoting fatty acid metabolism, PI3K inhibitor CYH33 triggers antitumor immunity in murine breast cancer by activating CD8+T cells and promoting fatty acid 新陈代谢, J Immunother Cancer, 2021.

（18）Adaptive resistance to PI3Kα-selective inhibitor CYH33 is mediated by genomic and transcriptomic alterations in ESCC cells, Adaptive resistance to PI3K-selective inhibitor CYH33 is mediated by genomic and transcriptomic alterations in ESCC cells, Cell Death Dis, 2021, 第12作者.

（19）CST6 protein and peptides inhibit breast cancer bone metastasis by suppressing CTSB activity and osteoclastogenesis, CST6 protein and peptides inhibit breast cancer bone metastasis by suppressing CTSB activity and osteoclastogenesis, Theranostics, 2021, 第12作者.

（20）Tumor microbiome contributes to an aggressive phenotype in the basal-like subtype of pancreatic cancer, Tumor microbiome contributes to an aggressive phenotype in the basal-like subtype of pancreatic cancer, Commun Biol, 2021.

（21）Identification of Key Genes With Differential Correlations in Lung Adenocarcinoma, Identification of Key Genes With Differential Correlations in Lung Adenocarcinoma, Front Cell Dev Biol, 2021, 第12作者.

（22）Brca2 deficiency drives gastrointestinal tumor formation and is selectively inhibited by mitomycin C, Brca2 deficiency drives gastrointestinal tumor formation and is selectively inhibited by mitomycin C, Cell 死亡 Dis, 2020, 第12作者.

（23）Natural Selection on Exonic SNPs Shapes Allelic Expression Imbalance (AEI) Adaptability in Lung Cancer Progression, Natural Selection on Exonic SNPs Shapes Allelic Expression Imbalance (AEI) Adaptability in Lung Cancer Progression, front Genet, 2020.

（24）Brca2 deficiency drives gastrointestinal tumor formation and is selectively inhibited by mitomycin C, CELL DEATH \u0026 DISEASE, 2020, 第11作者.

（25）Scd1 controls de novo beige fat biogenesis through succinate-dependent regulation of mitochondrial complex II, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 第12作者.

（26）Natural Selection on Exonic SNPs Shapes Allelic Expression Imbalance (AEI) Adaptability in Lung Cancer Progression, FRONTIERS IN GENETICS, 2020, 第10作者, 通讯作者.

（27）Identifying circulating miRNA biomarkers for early diagnosis and monitoring of lung cancer, Identifying circulating miRNA biomarkers for early diagnosis and monitoring of lung cancer, Biochim Biophys Acta Mol Basis Dis, 2020.（28）Scd1 controls de novo beige fat biogenesis through succinate-dependent regulation of mitochondrial complex II, Scd1 controls de novo beige fat biogenesis through succinate-dependent regulation of mitochondrial complex II, Proc Natl Acad Sci U S A, 2020, 第12作者.

（29）ONECUT2 overexpression promotes RAS-driven lung adenocarcinoma progression, SCIENTIFIC REPORTS, 2019, 第8作者, 通讯作者.

（30）Sex-related 脱氧核糖核酸 methylation differences in B cell chronic lymphocytic 白血病, BIOLOGY OF SEX DIFFERENCES, 2019, 第5作者.

（31）A computational method using the random walk with restart algorithm for identifying novel epigenetic factors, MOLECULAR GENETICS AND GENOMICS, 2018, 第5作者, 通讯作者.

（32）Distinguishing three subtypes of hematopoietic cells based on gene expression profiles using a support vector machine, BBA - MOLECULAR BASIS OF DISEASE, 2018, 第5作者.

（33）Distinguishing three subtypes of hematopoietic cells based on gene expression profiles using a support vector machine, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2018, 第5作者, 通讯作者.

（34）Identification of the core regulators of the HLA I-peptide binding process, SCIENTIFIC REPORTS, 2017, 第7作者, 通讯作者.

（35）Identifying and analyzing different cancer subtypes using 核糖核酸seq data of blood platelets, ONCOTARGET, 2017, 第8作者 通讯作者.

（36）Identifying New Candidate Genes and Chemicals Related to Prostate Cancer Using a Hybrid Network and Shortest Path Approach, COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE, 2015, 第7作者, 通讯作者.

（37）Genome-Wide Association Studies of HIV-1 Host Control in Ethnically Diverse Chinese Populations, SCIENTIFIC REPORTS, 2015, 第14作者.

（38）Integrative Analysis Reveals Enhanced Regulatory Effects of Human Long Intergenic Non-Coding RNAs in Lung Adenocarcinoma, JOURNAL OF GENETICS AND GENOMICS, 2015, 第12作者.

（39）Identifying Novel Candidate Genes Related to Apoptosis from a Protein-Protein Interaction Network, HINDAWI PUBLISHING CORPORATION, 2015, 第1作者.

（40）Alternative splicing at GYNNGY 5 splice sites: more noise, less regulation, NUCLEIC ACIDS RESEARCH, 2014, 第10作者, 通讯作者.

（41）COL4A3 mutations cause focal segmental glomerulosclerosis, JOURNAL OF MOLECULAR CELL BIOLOGY, 2014, 第14作者.

（42）Exome sequencing identifies frequent mutation of MLL2 in non small cell lung carcinoma from Chinese patients, SCIENTIFIC REPORTS, 2014, 第15作者.

（43）Genes That Escape X-Inactivation in Humans Have High Intraspecific Variability in Expression, Are Associated with Mental Impairment but Are Not Slow Evolving, MOLECULAR BIOLOGY AND EVOLUTION, 2013, 第11作者.

（44）Identification of Two Maternal Transmission Ratio Distortion Loci in Pedigrees of the Framingham Heart Study, SCIENTIFIC REPORTS, 2013, 第6作者, 通讯作者.

（45）Genome-Wide Interaction-Based Association Analysis Identified Multiple New Susceptibility Loci for Common Diseases, PLOS GENETICS, 2011, 第11作者.

（46）SKAP2, a novel target of HSF4b, associates with NCK2/F-actin at membrane ruffles and regulates actin reorganization in lens cell, JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2011, 第8作者.

（47）Evidence for OTUD-6B Participation in B Lymphocytes Cell Cycle after 细胞因子 Stimulation, PLOS ONE, 2011, 第 4 作者

（48）Nonsense-mediated decay targets have multiple sequence-related features that can inhibit translation, MOLECULAR SYSTEMS BIOLOGY, 2010, 第9作者, 通讯作者.

（49）Predicting Drug-Target Interaction Networks Based on Functional Groups and Biological Features, PLOS ONE, 2010, 第5作者.

（50）Length of the ORF, position of the first AUG and the Kozak motif are important factors in potential dual-coding transcripts, Length of the ORF, position of the first AUG and the Kozak motif are important factors in potential dual-coding transcripts, 细胞研究：英文版, 2010, 第14作者.

（51）Loss-of-函数 Mutations in the PRPS1 Gene Cause a Type of Nonsyndromic X-linked Sensorineural Deafness, DFN2, AMERICAN JOURNAL OF HUMAN GENETICS, 2010, 第11作者.

（52）Identification of vimentin as a novel target of hsf4 in lens development and cataract by proteomic analysis, INVESTIGATIVE OPHTHALMOLOGY \u0026 VISUAL SCIENCE, 2010, 第7作者.

（53）Stearoyl-CoA desaturase 1 deficiency protects mice from immune-mediated liver injury, LABORATORY INVESTIGATION, 2009, 第9作者.

（54）Gain-of-Function Mutation of KIT 配体 on Melanin Synthesis Causes Familial Progressive Hyperpigmentation, AMERICANJOURNALOFHUMANGENETICS, 2009, 第15作者, 通讯作者.

（55）Noisy splicing, more than expression regulation, explains why some exons are subject to nonsense-mediated mRNA decay, BMC BIOLOGY, 2009, 第6作者, 通讯作者.

（56）Dosage compensation on the active X chromosome minimizes transcriptional noise of X-linked genes in mammals, GENOME BIOLOGY, 2009, 第7作者.

（57）Divergence of exonic splicing elements after gene duplication and the impact on gene structures, GENOME BIOLOGY, 2009, 第7作者, 通讯作者.

（58）Removal of Hsf4 leads to 白内障 development in mice through down-regulation of gamma S-crystallin and Bfsp expression, BMC MOLECULAR BIOLOGY, 2009, 第8作者, 通讯作者.

（59）Triphalangeal Thumbpolysyndactyly 综合征 and syndactyly type IV are caused by genomic duplications involving the long range, limb-specific SHH enhancer, JOURNAL OF MEDICAL GENETICS, 2008.

（60）Alternative Promoters Influence Alternative Splicing at the Genomic Level, PLOS ONE, 2008, 第3作者.

（61）Evidence for common short natural trans sense-antisense pairing between transcripts from protein coding genes, GENOME BIOLOGY, 2008, 第6作者, 通讯作者.

（62）Activation of paternally expressed imprinted genes in newly derived germline-competent mouse parthenogenetic embryonic stem cell lines, CELL RESEARCH, 2007, 第8作者.

（63）Association of IL4R gene polymorphisms with asthma in Chinese populations, Hum Mutat, 2007, 第1作者, 通讯作者.

（64）Temporal and parental-specific expression of imprinted genes in a newly derived Chinese human embryonic stem cell line and embryoid bodies, HUMAN MOLECULAR GENETICS, 2006.

（65）Simple sequence repeat-based consensus linkage map of Bombyx mori, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005.

（66）Epigenetic inactivation of DLC-1 in supratentorial primitive neuroectodermal tumor, HUMAN 病理学, 2005.

（67）CYLD Mutation Causes Multiple Familial Trichoepithelioma in Three Chinese Families, HUMAN MUTATION, 2004, 第10作者, 通讯作者.

（68）Molecular evolution of the 严重急性呼吸综合征 正冠状病毒亚科 during the course of the sars epidemic in china, SCIENCE, 2004.

（69）Embryonic stem cells generated by nuclear transfer of human somaticnuclei into rabbit oocytes, Embryonic stem cells generated by nuclear transfer of human somatic nuclei into 兔形目 oocytes, CELL RESEARCH, 2003.

（70）Mutant 脱氧核糖核酸binding domain of HSF4 is associated with autosomal dominant lamellar and Marner 白内障, NATURE GENETICS, 2002.

（71）Dentinogenesis imperfecta 1 with or without progressive hearing loss is associated with distinct mutations in DSPP (vol 27, pg 201, 2001), NATURE GENETICS, 2001.

注：资料来源

荣誉

孔祥银研究员曾获国家自然科学二等奖，上海市科技进步二等奖，上海市科技进步一等奖， 2004年获第八届中国青年科技奖，以及第八届中国科学院十大杰出青年，2006年获上海市领军人才称号。

参考资料

孔祥银.中国科学院大学.2024-10-29