简单百科
李艳华

李艳华

李艳华，东北农业大学动物医学学院，教授，博士生导师，动物药学系主任。现为国家生猪产业技术体系岗位科学家、中国畜牧兽医学会兽医药理与毒理学分会常务理事、黑龙江省畜牧兽医学会常务理事、黑龙江省畜牧兽医杂志编委、中兽药产业技术创新战略联盟理事、兽用化学药品技术创新战略联盟理事、河南省洛阳惠中兽药有限公司专家顾问团成员。

科研项目

1.“十二五”国家科技支撑项目抗猪链球菌病复方制剂的研制，50万，主持

2.国家自然基金项目丁香茶干预2 型猪链球菌生物被膜形成的有效成分及其对cps基因簇调控研究，84万，主持

3.“十二五”国家科技支撑项目防治猪流感中兽药的研制与开发，140万，主持

4.教育部博导联合基金大环内类药物对猪链球菌体内生物被膜作用及对QS 系统影响的研究，6万，主持

5.哈尔滨市创新人才研究专项大环内酯类药物对猪链球菌生物被膜QS系统信号分子AI-2、CSP的影响,3万，主持

6.黑龙江省留学归国人员科学基金大环内酯类药物对猪链球菌生物被膜QS信号分子的作用，5万，主持

7.黑龙江省教育厅科学技术研究项目大环内酯类药物对猪链球菌体外生物被膜的作用及毒力因子影响，2万，主持

省部级以上奖励

1.第十二届黑龙江省青年科技奖

2.高效筛选农用抗生素体系构建及产多拉菌素新菌株发现与产业化黑龙江省科学技术发明奖一等奖

3.猪链球菌耐药性研究及安全高效新兽药的研制黑龙江省科学技术发明奖二等奖

4.禽流感病毒H5和H9亚型灭活疫苗研制与应用全国农牧渔业丰收奖二等奖

近五年发表文章

Ding W Y; Zhou Y H; Qu Q W; Cui W Q; God'spower B O; Liu Y Y; Li Y H*. Azithromycin Inhibits Biofilm Formation by 葡萄球菌 xylosus and Affects Histidine Biosynthesis Pathway[J]. Frontiers in 药理学, 2018.

Liu Y Y; Chen X R; Gao L F; Chen M; Cui W Q; Ding W Y; Chen X Y; God'spower B O; Li Y H*. spectrumeffect Relationships between the Bioactive Ingredient ofSyringa oblata Lindl. Leaves and its Role in Inhibiting the Biofilm Formation of Streptococcus suis[J]. Frontiers in 药理学, 2018.

Ding W Y;Sun J;Lian H;Xu C G;Liu X;Zheng S D;Zhang D;Han X P;Liu Y Y;Chen X Y,God'spower B O; Li Y H *. The Influence of Shuttle-Shape 大黄素 Nanoparticles on the 链球菌 suiBiofilm[J].Frontiers in 药理学,2018

Zhou Y H;Xu C G;Yang Y B;Xing X X;Liu X;Qu Q W;Ding W Y;Bello-Onaghise G; Li Y H *. Histidine 新陈代谢 and IGPD Play a Key Role in Cefquinome Inhibiting Biofilm Formation of 葡萄球菌 xylosus.[J]. Frontiers in 药理学, 2018, 9:665.

Li Y H;Zhou Y H;Ren Y Z;Xu C G;Liu X;Liu B;Chen J Q;Ding W Y;Zhao Y L;Yang Y B;Wang S;Liu D. Inhibition of 链球菌 suis Adhesion and Biofilm Formationin Vitroby 液态水 Extracts of Rhizoma Coptidis[J]. Frontiers in 药理学, 2018, 9.

Liu Y Y;Wang T Z;Ding W Y;Dong C L;Wang X T;Chen J Q; Li Y H *. Dissolution and oral bioavailability enhancement of praziquantel by solid dispersions.[J]. Drug Deliv Transl Res, 2018(2):1-11.

Bai, J W;Yang Y B;Wang S;Gao L F;Chen J Q;Ren Y Z;Ding W Y;Muhammad I; Li Y H *. Syringa oblata Lindl. Aqueous Extract Is a Potential Biofilm Inhibitor in S. suis[J]. Frontiers in 药理学, 2017, 8(e89059):26.

Wang S;Wang C;Gao L F;Cai H;Zhou Y H;Yang Y B;Xu C G; Ding W Y; Chen J Q;Muhammad I; Li Y H *. Rutin Inhibits 链球菌 suis Biofilm Formation by Affecting CPS Biosynthesis[J]. Frontiers in 药理学, 2017, 8:379

Ding W Y;Li Y H;Lian H;Ai X Y;Zhao Y L;Yang Y B;Han Q;Liu X;Chen X Y;He Z G; Li Y H *. Sub-Minimum Inhibitory Concentrations of Rhubarb 液态水 Extracts Inhibit 链球菌 suis Biofilm Formation[J]. Frontiers in 药理学, 2017, 8:379

Xu C G;Yang Y B;Zhou Y H;Hao M Q;Ren Y Z;Wang X T;Chen J Q;Muhammad I;Wang S;Liu D; Li Y H *. Comparative Proteomic Analysis Provides insight into the Key Proteins as Possible Targets Involved in Aspirin Inhibiting Biofilm Formation of 葡萄球菌 xylosus.[J]. Frontiers in 药理学, 2017, 8:543

Liu X;Zheng S D;Qin Y;Ding W Y;Tu Y B;Chen, X R;Wu Y Z;Li Y H;Cai X H. Experimental Evaluation of the Transport Mechanisms of PoIFN MAG通用机枪α in Caco-2 Cells[J]. Frontiers in Pharmacology, 2017, 8:781

Chen X R;Wang X T;Hao M Q;Zhou Y H;Cui W Q;Xing X X;Xu C G;Bai J W;Li Y H*. Homology Modeling and Virtual Screening to Discover Potent Inhibitors Targeting the Imidazole Glycerophosphate Dehydratase Protein in 葡萄球菌 xylosus.[J]. Frontiers in 化学, 2017, 5:9

S. Wang, Y.B. Yang, Y.L. Zhao, H.H. Zhao, J.W. Bai, J.Q. Chen, Y.H. Zhou, C. Wang, and Y.H. Li*, Sub-MIC Tylosin Inhibits Streptococcus suis Biofilm Formation and Results in Differential Protein Expression, Frontiers in Microbiology,Vol (7),No. 26, 1-9, 2016

Y.B. Yang, J.Q. Chen, Y.L. Zhao, J.W. Bai, W.Y. Ding, Y.H. Zhou, X.Y. Chen, D. Liu, and Y.H. Li*, Sub-MICs of Azithromycin Decrease Biofilm Formation of 链球菌 suis and Increase Capsular 多糖 Content of S. suis, Frontiers in Microbiology, Vol(7), No. 1-8, 2016

Y.B. Yang, S. Wang, C. Wang, Q.Y. Huang, J.W. Bai, J.Q. Chen, X.Y. Chen, and Y.H. Li*, Emodin affects biofilm formation and expression of virulence factors in Streptococcus suis ATCC700794, Archives of Microbiology,Vol (197), No. 10, 1173-1180,2015

Y.L. Zhao, Y.H. Zhou, J.Q. Chen, Q.Y. Huang, Q. Han, B. Liu, G.D. Cheng, and Y.H. Li*, Quantitative proteomic analysis of sub-MIC 红霉素 inhibiting biofilm formation ofS-suis in vitro, Journal of Proteomics,Vol (116), No.1-14,2014

大前锋 Wan, Z.L. Sheng, Q. Han, Y.L. Zhao, G.D. Cheng, and Y.H. Li*, Enrichment and purification of total flavonoids from Flos Populi extracts with macroporous resins and evaluation of antioxidant activities in vitro, Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences,Vol (945),No.68-74,2014

G.D. Cheng, Y.L. Zhao, H. Li, Y. Wu, X.X. Li, Q. Han, 计算机科学 Dai, and Y.H. Li*, Forsythiaside attenuates 脂多糖induced inflammatory responses in the bursa of Fabricius of chickens by downregulating the NF-kappa B signaling pathway, Experimental and Therapeutic Medicine, Vol(7), No.1,179-184, 2014

Z. Sheng, Y. Wang, P. Wan, and Y.H. Li*, ULTRASOUND-ASSISTED EXTRACTION OF TOTAL FLAVONOIDS FROM LEAVES OF SYRINGA OBLATA LINDL, Latin American Applied Research, Vol(44),二氧化氮, 131-131, 2014

X. Gao, G. Xu, Y. Liu, J.Q. Chen, Y. Cui, G.D. Cheng, Q.B. Yan, and Y.H. Li*, Validation of a UPLC/MS/MS Method for Determination of Compound Amoxicillin and Tylosin in Swine Plasma and its Application in a Pharmacokinetic Study, Journal of Pure and Applied Microbiology,Vol (7), No. 655-662,2013

Z.L. Sheng, 大前锋 Wan, C.L. Dong, and Y.H. Li*, Optimization of total flavonoids content extracted from Flos Populi using response surface methodology, Industrial Crops and Products,Vol (43), No.778-786,2013

任涌志#,高凌飞，王小婷，陈俭清，李艳华. 车前草水提物抗腹泻作用的研究[J]. 黑龙江畜牧兽医,2016,(18):168-170.

徐长赓#,周永辉，杨艳北，郝美琪，陈俭清，李艳华*. 阿司匹林对木糖葡萄球菌体外生物被膜的作用[J]. 中国兽医杂志,2016,(06):33-38.

王小婷#,蒋国政，王海滨，王凤霞，李艳华*,盛尊来. 乌梅肉提取物抗腹泻作用研究[J]. 中国现代应用药学,2016,(04):407-410.

陈俭清#,高凌飞，任涌志，盛尊来，姜岩，高利，李艳华*. 响应面法优化丁香叶总皂提取工艺[J]. 食品工业科技,2016,(10):320-328.

郝美琪#,杨艳北，周永辉，徐长庚，陈俭清，陈雪英，李艳华*. 大环内酯类药物对木糖葡萄球菌生物被膜形成的影响[J]. 中国兽医学,2015,(11):1206-1210.

高凌飞#,陈俭清，盛尊来，刘霄磊，魏树阁，张丛禄，房良，李艳华*. 丁香茶干预猪链球菌体外生物被膜形成有效部位的筛选[J]. 黑龙江畜牧兽医,2015,(13):189-191.

刘冰#,韩强，盛尊来，陈俭清，陈雪英，魏树阁，李艳华*. 黄连水提物盐酸小碱及黄连碱对猪链球菌生物被膜的体外干预作用[J]. 中国兽医杂志,2015,(04):16-19.

周永辉#,王淑杰，黄全勇，陈俭清，李艳华*. 猪链球菌的分型鉴定及其体外形成生物被膜的研究[J]. 中国兽医杂志,2014,(12):3-5.

吴燕#,盛尊来，高凌飞，陈俭清，李艳华*. 响应面法优化丁香茶总酚酸提取工艺[J]. 食品工业科技,2014,(02):286-290.

黄全勇#,韩强，陈俭清，赵玉林，闫清波，盛尊来，周永辉，李艳华*. 丁香叶水提物对猪链球菌体外生物被膜的作用[J]. 中国兽医杂志,2014,(07):29-35.

董春柳#,刘艳艳，王天梓，佟恒敏，李艳华*. 阿苯达唑固体分散体的制备及分析[J]. 畜牧兽医学报,2014,(06):1018-1023.

程广东#,岳丽红，吕冬云，盛尊来，李盛举，张强，王伟娥，张伟，赵玉林，李艳华*. 连翘酯苷A抗LPS介导大鼠类风湿性关节炎机制研究[J]. 东北农业大学学报,2014,(06):103-108.